High-Throughput Bioscience Center (HTBC)

HTBC Publications

HTBC users are requested to acknowledge the Stanford High-Throughput Bioscience Center in all publications that have results generated from HTBC equipment or services.   Users should also acknowledge appropriate HTBC support mechanisms such as, the Stanford Cancer Center, Digestive Disease Center, Spectrum, SPARK, or instrumentation grant number.

2016

  1. Screening of NCI-DTP library to identify new drug candidates for Borrelia burgdorferi.
    Pothineni VR, Wagh D, Babar MM, Inayathullah M, Watts RE, Kim KM, Parekh MB, Gurjarpadhye AA, Solow-Cordero D, Tayebi L, Rajadas J.
    J Antibiot (Tokyo). 2016 Nov 9. doi: 10.1038/ja.2016.131. [Epub ahead of print]. PubMedID: 27826144
  2. An in vivo multiplexed small-molecule screening platform.
    Grüner BM, Schulze CJ, Yang D, Ogasawara D, Dix MM, Rogers ZN, Chuang CH, McFarland CD, Chiou SH, Brown JM, Cravatt BF, Bogyo M, Winslow MM.
    Nat Methods. 2016 Oct;13(10):883-9. DOI: 10.1038/nmeth.3992. PubMedID: 27617390 PMCID: PMC5088491
  3. Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage.
    Stork CT, Bocek M, Crossley MP, Sollier J, Sanz LA, Chédin F, Swigut T, Cimprich KA.
    Elife. 2016 Aug 23;5. pii: e17548. doi: 10.7554/eLife.17548. [Epub ahead of print]. PubMedID: 27552054
  4. Combinatorial extracellular matrix microenvironments promote survival and phenotype of human induced pluripotent stem cell-derived endothelial cells in hypoxia.
    Hou L, Coller J, Natu V, Hastie TJ, Huang NF.
    Acta Biomater. 2016 Oct 15;44:188-99. DOI: 10.1016/j.actbio.2016.08.003.

    PubMedID:27498178 PMCID: PMC5045796

  5. Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction.
    Sclip A, Bacaj T, Giam LR, Südhof TC.
    PLoS One. 2016 Jun 27;11(6):e0158295. DOI: 10.1371/journal.pone.0158295.

    PubMedID:27348751 PMCID: PMC4922586

  6. Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Cytotoxic to Human Multiple Myeloma.
    Jiang D, Tam A, Alagappan M, Hay MP, Gupta A, Kozak M, Solow-Cordero DE, Lum PY, Denko N, Giaccia AJ, Le QT, Niwa M, Koong AC.
    Mol Cancer Ther. 2016 Jun 15. DOI: 10.1158/1535-7163.MCT-15-1023. [Epub ahead of print]. PubMedID: 27307600
  7. Glucose-6-Phosphate Dehydrogenase Deficiency and the Need for a Novel Treatment to Prevent Kernicterus.
    Cunningham AD, Hwang S, Mochly-Rosen D.
    Clin Perinatol. 2016 Jun;43(2):341-54. doi: 10.1016/j.clp.2016.01.010. Epub 2016 Feb 28. DOI: 10.1016/j.clp.2016.01.010. PubMedID: 27235212
  8. Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening.
    Pothineni VR, Wagh D, Babar MM, Inayathullah M, Solow-Cordero D, Kim KM, Samineni A, Parekh M, Tayebi L, Rajadas J
    Drug Design, Development and Therapy. 2016 Apr 1; 10: 1307–1322. doi:10.2147/DDDT.S101486. PubMedID: 27103785 Press Release
  9. Small molecule screen for inhibitors of expression from canonical CREB response element-containing promoters.
    Mitton B, Hsu K, Dutta R, Tiu BC, Cox N, McLure KG, Chae HD, Smith M, Eklund EA, Solow-Cordero DE, Sakamoto KM.
    Oncotarget. 2016 Feb 23;7(8):8653-62. doi: 10.18632/oncotarget.7085. [Epub ahead of print]. PubMedID: 26840025
  10. The primate-specific noncoding RNA HPAT5 regulates pluripotency during human preimplantation development and nuclear reprogramming.
    Durruthy-Durruthy J, Sebastiano V, Wossidlo M, Cepeda D, Cui J, Grow EJ, Davila J, Mall M, Wong WH, Wysocka J, Au KF, Reijo Pera RA.
    Nat Genet. 2016 Jan;48(1):44-52. doi: 10.1038/ng.3449. Epub 2015 Nov 23. PubMedID: 26595768

2015

  1. Oxygen regulation of breathing through an olfactory receptor activated by lactate.
    Chang AJ, Ortega FE, Riegler J, Madison DV, Krasnow MA.
    Nature. 2015 Nov 12;527(7577):240-4. doi: 10.1038/nature15721. PubMedID: 26560302
  2. A small-molecule antivirulence agent for treating Clostridium difficile infection.
    Bender KO, Garland M, Ferreyra JA, Hryckowian AJ, Child MA, Puri AW, Solow-Cordero DE, Higginbottom SK, Segal E, Banaei N, Shen A, Sonnenburg JL, Bogyo M.
    Sci Transl Med. 2015 Sep 23;7(306):306ra148. doi: 10.1126/scitranslmed.aac9103. Epub 2015 Sep 23. PubMedID: 26400909 Press Release
  3. Cell-Based High-Throughput Screening Identifies Rifapentine as an Inhibitor of Amyloid and Biofilm Formation in Escherichia coli.
    Maher MC, Lim JY, Gunawan C, Cegelski L.
    ACS Infect. Dis., 2015 Oct 9, 1 (10), pp 460–468. DOI: 10.1021/acsinfecdis.5b00055. Epub 2015 July 27. PubMedID: 27623312
  4. Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease.
    Hwang S, Disatnik MH, Mochly-Rosen D.
    EMBO Mol Med. 2015 Aug 12. pii: e201505256. doi: 10.15252/emmm.201505256. [Epub ahead of print]. PubMedID: 26268247
  5. Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension.
    Spiekerkoetter E, Sung YK, Sudheendra D, Bill M, Aldred MA, van de Veerdonk MC, Vonk Noordegraaf A, Long-Boyle J, Dash R, Yang PC, Lawrie A, Swift AJ, Rabinovitch M, Zamanian RT.
    Am J Respir Crit Care Med. 2015 Jul 15;192(2):254-7. doi: 10.1164/rccm.201411-2061LE. PubMedID: 26177174
  6. Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.
    Chen CH, Cruz LA, Mochly-Rosen D.
    Proc Natl Acad Sci U S A. 2015 Feb 23. pii: 201414657. [Epub ahead of print]. PubMedID: 25713355 Press Release
  7. MicroRNA-200c Contributes to Injury From Transient Focal Cerebral Ischemia by Targeting Reelin.
    Stary CM, Xu L, Sun X, Ouyang YB, White RE, Leong J, Li J, Xiong X, Giffard RG.
    Stroke. 2015 Feb;46(2):551-6. doi: 10.1161/STROKEAHA.114.007041. Epub 2015 Jan 20. PubMedID: 25604249
  8. A simple real-time assay for in vitro translation.
    Capece MC, Kornberg GL, Petrov A, Puglisi JD.
    RNA. 2015 Feb;21(2):296-305. doi: 10.1261/rna.047159.114. Epub 2014 Dec 18. PubMedID: 25525154
  9. AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.
    Neveu G, Ziv-Av A, Barouch-Bentov R, Berkerman E, Mulholland J, Einav S.
    J Virol. 2015 Apr;89(8):4387-404. doi: 10.1128/JVI.02705-14. Epub 2015 Feb 4. PubMedID: 25653444

2014

  1. p53 suppresses muscle differentiation at the myogenin step in response to genotoxic stress.
    Yang ZJ, Kenzelmann Broz D, Noderer WL, Ferreira JP, Overton KW, Spencer SL, Meyer T, Tapscott SJ, Attardi LD, Wang CL.
    Cell Death Differ. 2014 Dec 12. doi: 10.1038/cdd.2014.189. [Epub ahead of print]. PubMedID: 25501595
  2. Proteostatic Control of Telomerase Function through TRiC-Mediated Folding of TCAB1.
    Freund A, Zhong FL, Venteicher AS, Meng Z, Veenstra TD, Frydman J, Artandi SE.
    Cell. 2014 Dec 4;159(6):1389-403. doi: 10.1016/j.cell.2014.10.059. Epub 2014 Nov 20. PubMedID: 25467444
  3. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1.
    Gomes KM, Bechara LR, Lima VM, Ribeiro MA, Campos JC, Dourado PM, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC.
    Int J Cardiol. 2015 Jan 20;179:129-38. doi: 10.1016/j.ijcard.2014.10.140. Epub 2014 Oct 23. PubMedID: 25464432
  4. A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS Autoimmune Inflammatory Disease.
    Graham KL, Zhang JV, Lewén S, Burke TM, Dang T, Zoudilova M, Sobel RA, Butcher EC, Zabel BA.
    PLoS One. 2014 Dec 1;9(12):e112925. doi: 10.1371/journal.pone.0112925. eCollection 2014. PubMedID: 25437209
  5. Enhanced caspase activity contributes to aortic wall remodeling and early aneurysm development in a murine model of Marfan syndrome.
    Emrich FC, Okamura H, Dalal AR, Penov K, Merk DR, Raaz U, Hennigs JK, Chin JT, Miller MO, Pedroza AJ, Craig JK, Koyano TK, Blankenberg FG, Connolly AJ, Mohr FW, Alvira CM, Rabinovitch M, Fischbein MP.
    Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):146-54. doi: 10.1161/ATVBAHA.114.304364. Epub 2014 Oct 30. PubMedID: 25359856
  6. Therapeutic targeting of BRCA1-mutated breast cancers with agents that activate DNA repair.
    Alli E, Solow-Cordero D, Casey SC, Ford JM.
    Cancer Res. 2014 Nov 1;74(21):6205-15. doi: 10.1158/0008-5472.CAN-14-1716. Epub 2014 Sep 12. PubMedID: 25217519
  7. Hedgehog Signaling Restrains Bladder Cancer Progression by Eliciting Stromal Production of Urothelial Differentiation Factors.
    Shin K, Lim A, Zhao C, Sahoo D, Pan Y, Spiekerkoetter E, Liao JC, Beachy PA.
    Cancer Cell. 2014 Oct 13;26(4):521-533. doi: 10.1016/j.ccell.2014.09.001. PubMedID: 25314078
  8. Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain.
    Zambelli VO, Gross ER, Chen CH, Gutierrez VP, Cury Y, Mochly-Rosen D.
    Sci Transl Med. 2014 Aug 27;6(251):251ra118. doi: 10.1126/scitranslmed.3009539. PubMedID: 25163478 Press Release
  9. Arhgap36-dependent activation of Gli transcription factors.
    Rack PG, Ni J, Payumo AY, Nguyen V, Crapster JA, Hovestadt V, Kool M, Jones DT, Mich JK, Firestone AJ, Pfister SM, Cho YJ, Chen JK.
    Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11061-6. doi: 10.1073/pnas.1322362111. Epub 2014 Jul 14. PubMedID: 25024229 PMCID: PMC4121843
  10. Infection by Toxoplasma gondii specifically induces host c-Myc and the genes this pivotal transcription factor regulates.
    Franco M, Shastri AJ, Boothroyd JC.
    Eukaryot Cell. 2014 Apr;13(4):483-93. doi: 10.1128/EC.00316-13. Epub 2014 Feb 14. PubMedID: 24532536
  11. Characterization of a fluorescent probe for imaging nitric oxide.
    Ghebremariam YT, Huang NF, Kambhampati S, Volz KS, Joshi GG, Anslyn EV, Cooke JP.
    J Vasc Res. 2014;51(1):68-79. doi: 10.1159/000356445. Epub 2013 Dec 11. PubMedID: 24335468 PMCID: PMC3927988
  12. A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide.
    Ghebremariam YT, Erlanson DA, Cooke JP.
    J Pharmacol Exp Ther. 2014 Jan;348(1):69-76. doi: 10.1124/jpet.113.206847. Epub 2013 Oct 17. PubMedID: 24135074 PMCID: PMC3868884

2013

  1. Next-Generation NAMPT Inhibitors Identified by Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens.
    Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman JS, Cleary ML.
    Chem Biol. 2013 Nov 21;20(11):1352-63. Epub 2013 Oct 31. PubMedID: 24183972 PMCID: PMC3881547 Press Release
  2. NEK8 Links the ATR-Regulated Replication Stress Response and S Phase CDK Activity to Renal Ciliopathies.
    Choi HJ, Lin JR, Vannier JB, Slaats GG, Kile AC, Paulsen RD, Manning DK, Beier DR, Giles RH, Boulton SJ, Cimprich KA.
    Mol Cell. 2013 Aug 22;51(4):423-39. PubMedID: 23973373 PMCID: PMC3790667
  3. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion.
    Child MA, Hall CI, Beck JR, Ofori LO, Albrow VE, Garland M, Bowyer PW, Bradley PJ, Powers JC, Boothroyd JC, Weerapana E, Bogyo M.
    Nat Chem Biol. 2013 Oct;9(10):651-6. doi: 10.1038/nchembio.1315. Epub 2013 Aug 11. PubMedID: 23934245 PMCID: PMC3832678
  4. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.
    Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, Bernstein D, Solow-Cordero DE, Beachy PA, Wandless TJ, Dijke PT, Rabinovitch M.
    J Clin Invest. 2013 Aug 1;123(8):3600-13. Epub 2013 Jul 15. PubMedID: 23867624 PMCID: PMC3726153
  5. A c-Myc activation sensor-based high throughput drug screening identifies an anti-neoplastic effect of Nitazoxanide.
    Fan-Minogue H, Bodapati S, Solow-Cordero DE, Fan A, Paulmurugan R, Massoud T, Felsher DW, Gambhir SS.
    Mol Cancer Ther. 2013 Sep;12(9):1896-905. Epub 2013 Jul 3. PubMedID: 23825064 PMCID: PMC3772774
  6. Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine.
    Ghebremariam YT, LePendu P, Lee JC, Erlanson DA, Slaviero A, Shah NH, Leiper J, Cooke JP.
    Circulation. 2013 Aug 20;128(8):845-53. doi: 10.1161/CIRCULATIONAHA.113.003602. Epub 2013 Jul 3. PubMedID: 23825361 PMCID: PMC3838201
  7. A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth.
    Xiao N, Cao H, Chen CH, Kong CS, Ali R, Chan C, Sirjani D, Graves E, Koong A, Giaccia A, Mochly-Rosen D, Le QT.
    Clin Cancer Res. 2013 Aug 15;19(16):4455-64. Epub 2013 Jun 28. PubMedID:23812668 PMCID: PMC3745542
  8. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.
    Penchala SC1, Connelly S, Wang Y, Park MS, Zhao L, Baranczak A, Rappley I, Vogel H, Liedtke M, Witteles RM, Powers ET, Reixach N, Chan WK, Wilson IA, Kelly JW, Graef IA, Alhamadsheh MM.
    Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7. doi: 10.1073/pnas.1300761110. Epub 2013 May 28. PubMedID:23716704 PMCID: PMC3683741
  9. Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts.
    Davila J, Chanda S, Ang CE, Südhof TC, Wernig M.
    J Neurosci Methods. 2013 Jun 15;216(2):104-9. doi: 10.1016/j.jneumeth.2013.03.020. Epub 2013 Apr 3. PubMedID:23562599 PMCID: PMC4009399
  10. Oocyte-derived R-spondin2 promotes ovarian follicle development.
    Cheng Y, Kawamura K, Takae S, Deguchi M, Yang Q, Kuo C, Hsueh AJ.
    FASEB J. 2013 Jun;27(6):2175-84. doi: 10.1096/fj.12-223412. Epub 2013 Feb 13. PubMedID: 23407710 PMCID: PMC3659360
  11. The incorporation of extracellular matrix proteins in protein polymer hydrogels to improve encapsulated beta-cell function.
    Beenken-Rothkopf LN1, Karfeld-Sulzer LS, Davis NE, Forster R, Barron AE, Fontaine MJ.
    Ann Clin Lab Sci. 2013 Spring;43(2):111-21. PubMedID: 23694784
  12. Wnt/β-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3.
    Tao GZ, Lehwald N, Jang KY, Baek J, Xu B, Omary MB, Sylvester KG.
    J Biol Chem. 2013 Jun 14;288(24):17214-24. doi: 10.1074/jbc.M112.445965. Epub 2013 Apr 25. PubMedID:23620592 PMCID: PMC3682526
  13. The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch.
    Yang Q, Ferrell JE Jr.
    Nat Cell Biol. 2013 May;15(5):519-25. Epub 2013 Apr 28. PubMedID:23624406 PMCID: PMC3728279
  14. Genetically encoded multispectral labeling of proteins with polyfluorophores on a DNA backbone.
    Singh V, Wang S, Kool ET.
    J Am Chem Soc. 2013 Apr 24;135(16):6184-91. doi: 10.1021/ja4004393. Epub 2013 Apr 16. PubMedID:23590213 PMCID: PMC3646636
  15. A critical role for AID in the initiation of reprogramming to induced pluripotent stem cells.
    Bhutani N, Decker MN, Brady JJ, Bussat RT, Burns DM, Corbel SY, Blau HM.
    FASEB J. 2013 Mar;27(3):1107-13. Epub 2012 Dec 4. PubMedID:23212122 PMCID: PMC3574289
  16. Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons.
    Krey JF, Paşca SP, Shcheglovitov A, Yazawa M, Schwemberger R, Rasmusson R, Dolmetsch RE.
    Nat Neurosci. 2013 Feb;16(2):201-9. Epub 2013 Jan 13. PubMedID:23313911 PMCID: PMC3568452
  17. CD271(+) bone marrow mesenchymal stem cells may provide a niche for dormant Mycobacterium tuberculosis.
    Das B, Kashino SS, Pulu I, Kalita D, Swami V, Yeger H, Felsher DW, Campos-Neto A.
    Sci Transl Med. 2013 Jan 30;5(170):170ra13. doi: 10.1126/scitranslmed.3004912. PubMedID: 23363977 PMCID: PMC3616630

2012

  1. Identification and Characterization of a Potent Activator of P53-Independent Cellular Senescence Via a Small Molecule Screen for Modifiers of the Integrated Stress Response.
    Sayers CM, Papandreou I, Guttmann DM, Maas NL, Diehl JA, Witze ES, Koong AC, Koumenis C.
    Mol Pharmacol. 2013 Mar;83(3):594-604. doi: 10.1124/mol.112.081810. Epub 2012 Dec 10. PubMedID: 23229510 PMCID:PMC3583498
  2. SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.
    Jang KY, Noh SJ, Lehwald N, Tao GZ, Bellovin DI, Park HS, Moon WS, Felsher DW, Sylvester KG.
    PLoS One. 2012;7(9):e45119. Epub 2012 Sep 14. PubMedID: 23024800 PMCID:PMC3443243
  3. A time-resolved fluorescence resonance energy transfer assay suitable for high-throughput screening for inhibitors of immunoglobulin E-receptor interactions.
    Kim B, Tarchevskaya SS, Eggel A, Vogel M, Jardetzky TS.
    Anal Biochem. 2012 Dec 15;431(2):84-9. doi: 10.1016/j.ab.2012.09.010. Epub 2012 Sep 18. PubMedID: 22995065 PMCID:PMC3583350
  4. A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia.
    Dorn KV, Hughes CE, Rohatgi R.
    Dev Cell. 2012 Oct 16;23(4):823-35. doi: 10.1016/j.devcel.2012.07.004. Epub 2012 Sep 13. PubMedID: 22981989
  5. Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects.
    Chan CT, Reeves RE, Geller R, Yaghoubi SS, Hoehne A, Solow-Cordero DE, Chiosis G, Massoud TF, Paulmurugan R, Gambhir SS.
    Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2476-85. Epub 2012 Aug15. PubMedID: 22895790
  6. β-Catenin regulates hepatic mitochondrial function and energy balance in mice.
    Lehwald N, Tao GZ, Jang KY, Papandreou I, Liu B, Liu B, Pysz MA, Willmann JK, Knoefel WT, Denko NC, Sylvester KG.
    Gastroenterology. 2012 Sep;143(3):754-64. doi: 10.1053/j.gastro.2012.05.048. Epub 2012 Jun 7. PubMedID: 22684045
  7. HIF-2α suppresses p53 to enhance the stemness and regenerative potential of human embryonic stem cells.
    Das B, Bayat-Mokhtari R, Tsui M, Lotfi S, Tsuchida R, Felsher DW, Yeger H.
    Stem Cells. 2012 Aug;30(8):1685-95. doi: 10.1002/stem.1142. PubMedID: 22689594 PMCID: PMC3584519
  8. C-type natriuretic peptide stimulates ovarian follicle development.
    Sato Y, Cheng Y, Kawamura K, Takae S, Hsueh AJ.
    Mol Endocrinol. 2012 Jul;26(7):1158-66. doi: 10.1210/me.2012-1027. Epub 2012 May 17. PubMedID: 22595960 PMCID: PMC3385790
  9. Spatial positive feedback at the onset of mitosis.
    Santos SD, Wollman R, Meyer T, Ferrell JE Jr.
    Cell. 2012 Jun 22;149(7):1500-13. PubMedID: 22726437
  10. Development of a Dimethylarginine Dimethylaminohydrolase (DDAH) Assay for High-Throughput Chemical Screening.
    Ghebremariam YT, Erlanson DA, Yamada K, Cooke JP.
    J Biomol Screen. 2012 Jun;17(5):651-61. Epub 2012 Mar 29. PubMedID: 22460174
  11. Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice.
    Ning S, Budas GR, Churchill EN, Chen CH, Knox SJ, Mochly-Rosen D.
    Radiat Res. 2012 Jul;178(1):69-74. Epub 2012 Mar 9. PubMedID: 22404739 PMCID:PMC3417825
  12. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
    Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK.
    Nature. 2012 Mar 18;484(7392):125-9. doi: 10.1038/nature10936. PubMedID: 22425997 PMCID:PMC3321072
  13. Oxysterols are allosteric activators of the oncoprotein Smoothened.
    Nachtergaele S, Mydock LK, Krishnan K, Rammohan J, Schlesinger PH, Covey DF, Rohatgi R.
    Nat Chem Biol. 2012 Jan 8;8(2):211-20. doi: 10.1038/nchembio.765. PubMedID: 22231273

2011

  1. Neuropilins are positive regulators of Hedgehog signal transduction.
    Hillman RT, Feng BY, Ni J, Woo WM, Milenkovic L, Hayden Gephart MG, Teruel MN, Oro AE, Chen JK, Scott MP.
    Genes Dev. 2011 Nov 15;25(22):2333-46. doi: 10.1101/gad.173054.111. Epub 2011 Nov 3. Erratum in: Genes Dev. 2012 Mar 15;26(6):630.
    PubMedID: 22051878
  2. ALDH2 Activator Inhibits Increased Myocardial Infarction Injury by Nitroglycerin Tolerance.
    Sun L, Ferreira JC, Mochly-Rosen D.
    Sci Transl Med. 2011 Nov 2;3(107):107ra111.
    PubMedID: 22049071
  3. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases.
    Khanna M, Chen CH, Kimble-Hill A, Parajuli B, Perez-Miller S, Baskaran S, Kim J, Dria K, Vasiliou V, Mochly-Rosen D, Hurley TD.
    J Biol Chem. 2011 Dec 16;286(50):43486-94. Epub 2011 Oct 21.
    PubMedID: 22021038
  4. A Novel Aldehyde Dehydrogenase-3 Activator Leads to Adult Salivary Stem Cell Enrichment In Vivo.
    Banh A, Xiao N, Cao H, Chen CH, Kuo P, Krakow T, Bavan B, Khong B, Yao M, Ha C, Kaplan MJ, Sirjani D, Jensen K, Kong CS, Mochly-Rosen D, Koong AC, Le QT.
    Clin Cancer Res. 2011 Dec 1;17(23):7265-72. Epub 2011 Oct 13.
    PubMedID: 21998334
  5. Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.
    Alhamadsheh MM, Connelly S, Cho A, Reixach N, Powers ET, Pan DW, Wilson IA, Kelly JW, Graef IA.
    Sci Transl Med. 2011 Aug 24;3(97):97ra81.
    PubMedID: 21865539
  6. Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality.
    Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Banh A, Reynolds GE, Chi JT, Wu J, Solow-Cordero DE, Bonnet M, Flanagan JU, Bouley DM, Graves EE, Denny WA, Hay MP, Giaccia AJ.
    Sci Transl Med. 2011 Aug 3;3(94):94ra70.
    PubMedID: 21813754 Press Release SF Chronicle Front Page Article
  7. Wnt-β-catenin signaling protects against hepatic ischemia and reperfusion injury in mice.
    Lehwald N, Tao GZ, Jang KY, Sorkin M, Knoefel WT, Sylvester KG.
    Gastroenterology. 2011 Aug;141(2):707-18, 718.e1-5. doi: 10.1053/j.gastro.2011.04.051. Epub 2011 May 4.
    PubMedID: 21679710
  8. Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion.
    Hall CI, Reese ML, Weerapana E, Child MA, Bowyer PW, Albrow VE, Haraldsen JD, Phillips MR, Sandoval ED, Ward GE, Cravatt BF, Boothroyd JC, Bogyo M.
    Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10568-73. Epub 2011 Jun 13.
    PubMedID: 21670272
  9. SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells.
    Bonnet M, Flanagan JU, Chan DA, Lai EW, Nguyen P, Giaccia AJ, Hay MP.
    Bioorg Med Chem. 2011 Jun 1;19(11):3347-56. Epub 2011 Apr 24.
    PubMedID: 21561782
  10. The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein.
    Lee C, Ma H, Hang JQ, Leveque V, Sklan EH, Elazar M, Klumpp K, Glenn JS.
    Virology.  2011 May 25;414(1):10-8. Epub 2011 Apr 22.
    PubMedID: 21513964
  11. Differentiating between fluorescence-quenching metal ions with polyfluorophore sensors built on a DNA backbone.
    Tan SS, Kim SJ, Kool ET.
    J Am Chem Soc. 2011 Mar 2;133(8):2664-71. doi: 10.1021/ja109561e. Epub 2011 Feb 4.
    PubMedID: 21294558 PMCID: PMC3045473
  12. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration.
    Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ.
    Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1931-6. Epub 2011 Jan 13.
    PubMedID: 21233420

2010

  1. PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells.
    Kim J, Koyanagi T, Mochly-Rosen D.
    Prostate. 2011 Jun 15;71(9):946-54. doi: 10.1002/pros.21310. Epub 2010 Nov 23. PubMedID: 21541971
  2. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma.
    Papandreou I, Denko NC, Olson M, Van Melckebeke H, Lust S, Tam A, Solow-Cordero DE, Bouley DM, Offner F, Niwa M, Koong AC.
    Blood. 2011 Jan 27;117(4):1311-4. Epub 2010 Nov 16. PubMedID: 21081713
  3. Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models.
    Vicent S, Chen R, Sayles LC, Lin C, Walker RG, Gillespie AK, Subramanian A, Hinkle G, Yang X, Saif S, Root DE, Huff V, Hahn WC, Sweet-Cordero EA.
    J Clin Invest. 2010 Nov 1;120(11):3940-52. Epub 2010 Oct 25. PubMedID: 20972333 PMCID: PMC2965578
  4. The roles of cyclin A2, B1, and B2 in early and late mitotic events.
    Gong D, Ferrell JE Jr.
    Mol Biol Cell. 2010 Sep 15;21(18):3149-61. Epub 2010 Jul 21 PubMedID: 20660152 PMCID: PMC2938381
  5. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors.
    Einav S, Sobol HD, Gehrig E, Glenn JS.
    J Infect Dis. 2010 Jul 1;202(1):65-74 PubMedID: 20486856 PMCID: PMC3008401
  6. A small molecule inhibits HCV replication and alters NS4B's subcellular distribution.
    Bryson PD, Cho NJ, Einav S, Lee C, Tai V, Bechtel J, Sivaraja M, Roberts C, Schmitz U, Glenn JS.
    Antiviral Res. 2010 Jul;87(1):1-8. Epub 2010 Apr 2 PubMedID: 20363257
  7. Identification of a Class of HCV Inhibitors Directed Against the Nonstructural Protein NS4B.
    Cho NJ, Dvory-Sobol H, Lee C, Cho SJ, Bryson P, Masek, M, Elazar M, Frank CW, Glenn JS.
    Sci Transl Med 20 January 2010: Vol. 2, Issue 15, p. 15ra6 PubMedID: 20371471 PMCID: PMC3025298
    Press Release
  8. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.
    Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD.
    Nature Structural & Molecular Biology. 2010; Feb;17(2):159-64. Epub 2010 Jan 10. PubMedID: 20062057 PMCID: PMC2857674
    Press Release
  9. 4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell death.
    Hay MP, Turcotte S, Flanagan JU, Bonnet M, Chan DA, Sutphin PD, Nguyen P, Giaccia AJ, Denny WA.
    J Med Chem. 2010 Jan 28;53(2):787-97. PubMedID: 19994864 PMCID: PMC2838715

2009

  1. Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice.
    Budas GR, Disatnik, MH, Chen CH, Mochly-Rosen D.
    J Mol Cell Cardiol. 2010 Apr;48(4):757-64. Epub 2009 Nov 11. PubMedID: 19913552 PMCID: PMC2837767
  2. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
    Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK.
    Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7. Epub 2009 Aug 5. PubMedID: 19666565 PMCID: PMC2721821
  3. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.
    Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA.
    Mol Cell. 2009 Jul 31; 35 (2): 228-39 PubMedID: 19647519 PMCID: PMC2772893
  4. Molecular imaging of phosphorylation events for drug development.
    Chan CT, Paulmurugan R, Reeves RE, Solow-Cordero D, Gambhir SS.
    Mol Imaging Biol. 2009 May-Jun;11(3):144-58. Epub 2008 Dec 2. PubMedID: 19048345
  5. The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2alpha via protein kinase activated by double-stranded RNA activation.
    Elazar M, Liu M, McKenna SA, Liu P, Gehrig EA, Puglisi JD, Rossignol JF, Glenn JS.
    Gastroenterology. 2009 Nov;137(5):1827-35. Epub 2009 Aug 4. PubMedID: 19664635
  6. Noninflammatory gluten peptide analogs as biomarkers for celiac sprue.
    Bethune MT, Crespo-Bosque M, Bergseng E, Mazumdar K, Doyle L, Sestak K, Sollid LM, Khosla C.
    Chem Biol. 2009 Aug 28;16(8):868-81. PubMedID: 19716477
  7. Converse conformational control of smoothened activity by structurally related small molecules.
    Yang H, Xiang J, Wang N, Zhao Y, Hyman J, Li S, Jiang J, Chen JK, Yang Z, Lin S.
    J Biol Chem. 2009 Jul 31;284(31):20876-84. Epub 2009 Apr 14.
    PubMedID: 19366682 PMCID: PMC2742853
  8. Interferon-gamma released by gluten-stimulated celiac disease-specific intestinal T cells enhances the transepithelial flux of gluten peptides.
    Bethune MT, Siegel M, Howles-Banerji S, Khosla C.
    J Pharmacol Exp Ther. 2009 May;329(2):657-68. Epub 2009 Feb 13. PubMedID: 19218531 PMCID: PMC2672868
  9. Defective repair of oxidative dna damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymerase.
    Alli E, Sharma VB, Sunderesakumar P, Ford JM.
    Cancer Res. 2009; 69 (8): 3589-96. PubMedID: 19351835
  10. Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process.
    Rohatgi R, Milenkovic L, Corcoran RB, Scott MP.
    Proc Natl Acad Sci U S A. 2009; 106 (9): 3196-201. PubMedID: 19218434 PMCID: PMC2642660

2008

  1. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.
    Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D.
    Science. 2008; 321 (5895): 1493-5. PubMedID: 18787169 PMCID: PMC2741612 Press Release
  2. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy.
    Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA, Giaccia AJ.
    Cancer Cell. 2008; 14 (1): 90-102. PubMedID: 18598947 PMCID: PMC2819422
    Press Release
  3. Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death.
    Turcotte S, Sutphin PD, Giaccia AJ.
    Autophagy. 2008; 4 (7): 944-6. PubMedID: 18769110
  4. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis.
    Einav S, Gerber D, Bryson PD, Sklan EH, Elazar M, Maerkl SJ, Glenn JS, Quake SR.
    Nat Biotechnol. 2008; 26 (9): 1019-27. PubMedID: 18758449
    Press Release
  5. Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF.
    Pomerening JR, Ubersax JA, Ferrell JE.
    Mol Biol Cell. 2008; 19 (8): 3426-41. PubMedID: 18480403
  6. GLUT1 and GLUT9 as major contributors to glucose influx in HepG2 cells identified by a high sensitivity intramolecular FRET glucose sensor.
    Takanaga H, Chaudhuri B, Frommer WB.
    Biochim Biophys Acta. 2008; 1778 (4): 1091-9. PubMedID: 18177733

2007

  1. siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake.
    Galvez T, Teruel MN, Heo WD, Jones JT, Kim ML, Liou J, Myers JW, Meyer T.
    Genome Biol. 2007;8(7):R142. PubMedID: 17640392
  2. Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1.
    Gong D, Pomerening JR, Myers JW, Gustavsson C, Jones JT, Hahn AT, Meyer T, Ferrell JE.
    Curr Biol. 2007; 17 (1): 85-91. PubMedID: 17208191
  3. A transgenic mouse model for high content, cell cycle phenotype screening in live primary cells.
    Burney RO, Lee AI, Leong DE, Jones JT, Hahn AT, Meyer T, Yao MW.
    Cell Cycle. 2007; 6 (18): 2276-83. PubMedID: 17881898
  4. TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.
    Sklan EH, Serrano RL, Einav S, Pfeffer SR, Lambright DG, Glenn JS.
    Biol Chem. 2007 Dec 14;282(50):36354-61. Epub 2007 Sep 27. PubMedID: 17901050

2006

  •  

2005

  1. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.
    Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE, Meyer T.
    Curr Biol. 2005; 15 (13): 1235-41. PubMedID: 16005298
    Stanford Medicine: Anatomy of an Experiment Article
  2. The unfolded protein response: a novel component of the hypoxic stress response in tumors.
    Feldman DE, Chauhan V, Koong AC.
    Mol Cancer Res. 2005; 3 (11): 597-605. PubMedID: 16317085

 

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