DAVID E. SOLOW-CORDERO, Ph.D.
Department of Chemical & Systems
Biology
EDUCATION:
Ph.D.,
1995, Department of Molecular and Cellular Biology
Thesis
Title: In vitro Analysis of Rifampicin
Resistant Escherichia coli RNA
Polymerases
Michael
J. Chamberlin, Professor
University
Fellowship, September 1991 to July 1992
BS,
1990, Department of
Biology
Massachusetts
Institute of Technology
Anthony
J. Sinskey, Professor
National
Hispanic Scholar, September 1986 to May 1987
EMPLOYMENT
HISTORY:
Department
of Chemical & Systems Biology
September
2003 to Present
Responsibilities
include:
·
Select, purchase, program, and maintain laboratory robotics and
detection systems including a fully automate Caliper Life Sciences Staccato
cell based system (Sciclone ALH3000, Twister II,
automated incubator), a Velocity11 VPrep/BenchCel
system and Molecular Devices ImageXpress, AnalystGT, and Flexstation 384.
·
Select and purchase chemical libraries to be used for screening.
·
Identify and manage research collaborations with Stanford faculty and
students to incorporate high-throughput technologies in their research
programs.
·
Build, develop and manage the ORACLE based MDL cheminformatics
data systems (ChemBioAE, Plate Manager and Assay
Explorer).
·
Schedule and manage HTBC group including Scientists and Research
Associates. Oversee all financial and
administrative tasks of the HTBC, a Stanford service center.
·
Manage human whole genome RNA interference screens
·
Ceretek,
LLC.,
Principal
Scientist, High Throughput Screening (HTS) and Informatics
June
1999 to September 2003
Responsibilities
include:
·
Design, develop, scale-up, and validate G-Protein Coupled Receptor
assays for HTS
·
Select, purchase, program, and maintain laboratory robotics including a
Molecular Devices FLIPR384 and a Beckman Multimek.
·
Select and purchase chemical libraries to be used for HTS.
·
Schedule and manage HTS group including Scientists and Research
Associates.
·
Manage collaborations with chemists and biologists concerning screening
data and lead identification.
·
Build, develop and manage MDL cheminformatics
data system (ISIS Base/Host and ORACLE).
FibroGen,
Inc.,
Scientist,
Enzymology
July
1995 to June 1999
Responsibilities
include:
·
Design, develop, and scale-up assays for HTS
Including, characterization
and purification of procollagen/collagen processing enzymes, development of
robust scaleable assay to aid in the discovery of novel inhibitors of fibrosis.
·
Select, purchase, program, and maintain laboratory robotics.
·
Schedule and manage HTS group including Scientists and Research
Associates.
·
Build, develop and manage MDL cheminformatics
data system (ISIS Base/Host and ORACLE).
Graduate
Student
Thesis Advisor:
Michael J. Chamberlin, Professor
September 1990 to June 1995
·
Research on In vitro analysis of rifampicin resistant E.
coli RNA polymerases.
Rotation projects:
·
Research on
protein membrane translocation in yeast.
Randy Schekman, Professor
·
Research on
enzyme substrate channeling in yeast.
Jack Kirsch, Professor
Massachusetts Institute of Technology
Undergraduate Researcher
Advisor: Anthony J. Sinskey,
Professor
May 1988 to August 1990
·
Research on the allosteric inhibition by threonine
on homoserine dehydrogenase
in C. glutamicum.
Bayer, Inc.,
Elkhart, Indiana
Research Assistant
May 1987 to August 1987
·
Research on Aspergillus
Bayer, Inc.,
Laboratory Assistant
May 1986 to August 1986
HONORS
AND AWARDS:
1986-1987
National
Hispanic Scholar, MIT
1991-1992
University
Fellowship,
2005- Member, Study Section “Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (NIH, MLSCN) ”
2006- Member, Education Committee,
Society of Biomolecular Sciences (SBS)
PUBLICATIONS
AND PATENTS:
Twelve filed
One issued US Patent:
Solow-Cordero, D. Shankar, G., J.V. Spencer,
and C. Gluchowski.
Methods of treating conditions associated with an Edg-3 receptor. 7,208,502
Two International patent applications:
Shankar, G., Solow-Cordero, D., J.V. Spencer, and C. Gluchowski. Methods of treating conditions associated with an EDG receptor. WO 2003/062392, July 31, 2003.
Solow-Cordero, D., Shankar,
G., J.V. Spencer, and C. Gluchowski. Methods of treating conditions associated
with an EDG-1 receptor. WO 2004/009816,
Solow-Cordero, D.E. Academia catching up to
industry: How liquid handling is
enhancing basic research. G.I.T.
Laboratory Journal 3-4: 64-65
(2007).
Lee, S., Solow-Cordero, D.E., Kessler, E., Takahara, K., and Greenspan, D.S. Transforming growth
factor-b regulation of bone morphogenetic protein-1/procollagen C-proteinase
and related proteins in fibrogenic cells and
keratinocytes. J. Biol. Chem. 272: 19059-19066 (1997).
Altmann,
C.R.; Solow-Cordero, D.E.; Chamberlin, M.J.: RNA cleavage and chain elongation
by Escherichia coli DNA-dependent RNA
polymerase in a binary enzyme-RNA complex. Proc.Natl.Acad.Sci.USA.
91:
3784-3788 (1994).
Archer,
J.A.; Solow-Cordero, D.E.; Sinskey, A.J.: A C-terminal deletion in Corynebacterium glutamicum homoserine
dehydrogenase abolishes allosteric inhibition by l-threonine. Gene. 107:
53-59 (1991).
INVITED
LECTURES:
Laboratory Robotics Interest
Group (LRIG)-Bay Area
Meeting: Current Bottlenecks in Laboratory
Automation
Society for Biomedical
Screening (SBS) West Coast Regional
Meeting: Exploiting the Druggable
Genome:
21-22 April 2005,
Elsevier MDL Biology Data Management Exchange
5-6 May 2005,
RNAiGlobal-Dharmacon
25-26 September 2006,
RNAiGlobal-ThermoFisher
12-13 April 2007,
TEACHING
September to December 1994,
Instructor for Undergraduate Seminar:
Novel Reactions in Transcription Regulation (MCB 119)
January to May 1993,
Teaching Assistant for Introduction to Biology (MCB 15)
November 1991 to February
1992, Teaching Assistant for Biochemistry Lab (MCB 110L)
ASSOCIATIONS
Society for Biomolecular Sciences (SBS)
Association of Laboratory
Automation (
AAAS