High-Throughput Bioscience Center (HTBC)

Welcome to the High-Throughput Bioscience Center (HTBC)

HTBC IS USING iLABS FOR ALL SCHEDULING AND BILLING. PLEASE REGISTER HERE. Non-Stanford Researchers can register here External Researchers

**HTBC Discovery recently in the news: Study identifies potential anti-cancer therapy that starves cancer cells of glucose, San Francisco Chronicle Front Page Article (8/4/2011)

Discovering New Therapeutic Uses for Existing Molecules (current funding opportunities). Press Release from repurposed drug project done with the HTBC.

Assay Development Funding Opportunities (PAR-17-438)

The High-Throughput Bioscience Center's mission is to provide researchers at Stanford with the ability to run high-throughput chemical, siRNA, cDNA, and high-content screens for the purpose of drug and/or target discovery. The HTBC is a Stanford University School of Medicine core facility and was created in 2003 by the Department of Chemical and Systems Biology (formerly Molecular Pharmacology). The HTBC is a shared resource (Bioscience Screening Facility) for the Stanford Cancer Institute (more info), the NIH Clinical and Translational Science Award (Spectrum), and formerly the Digestive Disease Center (Chemical Genomics Core), .

This high-throughput screening (HTS) laboratory allows Stanford researchers and others to discover novel modulators of targets that otherwise would not be practical in industry. The center incorporates instrumentation (purchased with NCRR NIH Instrumentation grant numbers S10RR019513 and S10RR026338), databases, compound libraries, and personnel whose previous sole domains were in industry. Among our instrumentation are a Molecular Devices ImageXpress Micro High-Content fluorescence microplate imager, with live cell and phase contrast/brightfield options, a Caliper Life Sciences SciClone ALH3000 and an Agilent Bravo microplate liquid handler, and the Molecular Devices Analyst GT and FlexStation II 384 and Tecan Infinite M1000 and M1000 PRO fluorescence, luminescence and absorbance multimode microplate readers. We have over 130,000 small molecules for compound screens, 15,000 cDNAs for genomic screens, and whole genome siRNA libraries targeting the human genome (the siARRAY whole human genome siRNA library from Dharmacon, targeting 21,000 human genes) and the mouse genome (Qiagen mouse whole genome siRNA set V1 against 22,124 genes).

The HTBC is located in CCSR Room 0133-North Wing, between the Transgenic Research Center, the Human Immune Monitoring Core, and the Stanford Functional Genomics Facility. For directions or room access, see our Contact page.

For more information on our services please contact the HTBC Director, David E. Solow-Cordero (x5-6002).

HTBC News, Forms, and More Information Downloads:

HTBC iLAB Page for HTBC registration and to see equipment Calendars.

**HTBC Discovery in the news: Key enzyme for regulating heart attack damage found, Stanford scientists report, and Stanford researchers find molecule that kills kidney cancer cells, featured in NPR (link)** List of HTBC publications.

HTBC PDF Description, Powerpoint HTBC Summary Slides , HTBC Poster

Article on the HTBC in the Stanford Report (Oct. 6, 2004).

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