Welcome to the High-Throughput Bioscience Center (HTBC)

The High-Throughput Bioscience Center's mission is to provide researchers at Stanford with the ability to run high-throughput chemical, siRNA, cDNA, and high-content screens for the purpose of drug and/or target discovery. The HTBC is a Stanford University School of Medicine core facility and was created in 2003 by the Department of Chemical and Systems Biology (formerly Molecular Pharmacology). The HTBC is the newest core facility for the Stanford Comprehensive Cancer Center (more info) and the Digestive Disease Center.

Research approaches that were previously done exclusively in industry are now being used in academia to advance basic research. This high-throughput screening (HTS) laboratory allows Stanford researchers and others to discover novel modulators of targets that otherwise would not be practical in industry. The center incorporates instrumentation (purchased with NCRR NIH Instrumentation grant number 1S10RR019513-01), databases, compound libraries, and personnel whose previous sole domains were in industry. Among our instrumentation are a Molecular Devices ImageXpress Micro fluorescence microplate imager, with live cell option, a Caliper Life Sciences SciClone ALH3000 microplate liquid handler and the Molecular Devices Analyst GT and FlexStation II 384 fluorescence, luminescence and absorbance microplate readers. We have over 130,000 small molecules for compound screens, 12,000 cDNAs for genomic screens, and the siARRAY whole human genome siRNA library from ThermoFisher Scientific (formerly Dharmacon) targeting 21,000 genes.

The HTBC is located in CCSR Room 0133-North Wing, between the Transgenic Mouse Facility, the Immune Monitoring Core, and the Stanford Functional Genomics Facility. For directions or room access, see our Contact page.

For more information on our services please contact the HTBC Director, David E. Solow-Cordero (x5-6002).

Forms and More Information Downloads:

HTBC PDF Description, Powerpoint HTBC Summary Slides , HTBC Poster

siRNA Screen Application , User Registration Form, Screeners Agreement Form

Article on the HTBC in the Stanford Report (Oct. 6, 2004).